Generic name: Itraconazole Brand name: Cozule (by Horizon Pharmaceuticals) Strength: 100 mg per capsule Pack size: 4 capsules Category: Antifungal Medicines → Systemic Antifungals Mechanism of Action Itraconazole is a triazole antifungal. It works by inhibiting fungal cytochrome P450‑dependent enzymes, blocking ergosterol synthesis. This disrupts fungal cell membrane integrity, leading to cell death. Clinical Uses Dermatophytosis → skin and nail fungal infections. Onychomycosis → nail fungus treatment. Systemic mycoses → histoplasmosis, blastomycosis, aspergillosis. Side Effects Common: Nausea, abdominal pain, headache. Serious: Liver toxicity, heart failure risk. Precautions: Avoid in patients with cardiac disease; monitor liver function. Patient Counselling Points Take orally after meals for better absorption. Complete the full course as prescribed. Avoid alcohol during treatment. Store below 30°C, away from sunlight and moisture. Keep out of reach of children.